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队伍概况

 

姓名

刘曼莉

所在单位

湖北省生物农药工程研究中心

职称/职务

助理研究员

学科专业

预防兽医学

研究方向

新药筛选

联系电话

15926216663

电子信箱

15926216663@163.com

主要学习及工作经历:

2011/07-至今,永利集团游戏网址,湖北省生物农药工程研究中心,助理研究员

2005/09-2011/06,华中农业大学,预防兽医学,博士

2001/09-2005/06,华中农业大学,动物医学,学士

 

主要社会兼职情况:

 

 

目前主要研究领域:

动物传染病的新药筛选研究。

 

主持及参与项目(课题)情况(主要科技项目5项):

1、国家重点研发计划,2017YFD0500202,病原菌代谢调控机制研究,2017/07-2020/12, 在研,参与。

2、永利集团游戏网址青年科学基金,WS-32300代谢产物抗猪繁殖与呼吸综合征病毒的药效学研究2015/05-2017/05,主持。

3、先正达公司(瑞士),微生物源先导化合物的筛选,2011-至今,参与。

4、国家科技支撑计划,芽孢杆菌活菌制剂工程化技术开发及品种创制与示范,2011-2013,参与。

 

获得的科技奖励及专利、标准情况:

1)柯少勇,杨自文,石丽桥,刘曼莉,王开梅,梁英,江爱兵,共轭双烯衍生物及其制备方法与作为抗癌药物的用途,2016.03.02,中国,201310350441.X

 

代表性著作及论文发表情况:

1刘曼莉, 方六荣, 肖少波, 陈焕春, 谭臣, 石丽桥, 王开梅, 杨自文. 猪链球菌2型感染的A549细胞表达谱研究. 动物医学进展. 2017, (11): 6-10

2Manli Liu, Liurong Fang, Tiansi Long, Huanchun Chen, Shaobo Xiao. Understanding Streptococcus suis serotype 2 infection in pigs through a transcriptional approach. BMC Genomics. 2011 May 20; 12(1):253

3Manli Liu, Chen Tan, Liurong Fang, Shaobo xiao, Huanchun Chen. Microarray analyses of THP-1 cells infected with Streptococcus suis serotype 2. Vet microbiology. 2011, 150: 126-131.

4Lilan Xie(#), Manli Liu(#),Liurong FangXiuchan SuKaimei CaiDang WangHuanchun Chen, Shaobo Xiao. Molecular cloning and functional characterization of procine stimulator of interferon genes (STING). Developmental and Comparative Immunology. 2010, 34(8): 847-54.

5Yanyan Zhang, Dandan Ding, Manli Liu, Xiaopei Yang, Bingbing Zong, Xiangru Wang, Huanchun Chen, Weicheng Bei, Chen Tan, Effect of the glycosyltransferases on the capsular polysaccharide synthesis of Streptococcus suis serotype 2. Microbiological Research. 2016, 185:45-54.

6Yang Qingyu, Mao Qing, Liu Manli, Wang Kaimei, Wu Zhaoyuan, Fang Wei, Yang Ziwen, Luo Pengchen, Ke Shaoyong, Shi Liqiao*. The inhibitory effect of dehydroepiandrosterone and its derivatives against influenza A virus in vitro and in vivo.. Arch Virol, 2016, 161(11): 3061~3072.

7Wei Yanhong, Shi Liqiao, Wang Kaimei, Liu Manli, Yang Qingyu, Yang Ziwen, Ke Shaoyong*. Discovery of gramine derivatives that inhibit the early stage of EV71 replication in vitro.. Molecules, 2014, 19(7):8949~8964.

8Xu Juan, Fu Shulin, Liu Manli, Xu Qiaoxia, Bei Weicheng, Chen Huanchun, Tan Chen. The two-component system NisK/NisR contributes to the virulence of Streptococcus suis serotype 2. Microbiological Research. 2014, 169(7-8)541-546.

9Tan Chen, Liu Manli, Li Jinquan, Jin Meilin, Bei Weicheng, Chen  Huanchun. SsPep contributes to the virulence of Streptococcus suis. Microbial Pathogenesis. 2011, 51(5):319-324.

10Tan Chen, Liu Manli, Liu Jinlin, Yuan Fangyan, Fu Shulin, Liu Yuan, Jin Meilin, Bei Weicheng, Chen Huanchun. Vaccination with Streptococcus suis serotype 2 recombinant 6PGD protein provides protection against S-suis infection in swine. FEMS Microbiology Letters. 2009, 296(1):78-83.

11Tan Chen, Liu Manli, Jin Meilin, Liu Jinlin, Chen Yan, Wu Tao, Fu Ting, Bei Weicheng, Chen Huanchun. The key virulence-associated genes of Streptococcus suis type 2 are upregulated and differentially expressed in vivo. FEMS Microbiology Letters. 2008, 278(1):108-114.

12Tan Chen, Fu Shulin, Liu Manli, Jin Meilin, Liu Jinlin, Bei Weicheng, Chen Huanchun, Cloning, expression and characterization of a cell wall surface protein, 6-phosphogluconate-dehydrogenase, of Streptococcus suis serotype 2. Veterinary Microbiology. 2008, 130(3-4):363-370.

 

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